The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers. However, the mechanism underlying this malignancy development is unclear. To ...

From birth, our immune system is ready to spring into action to protect us from pathogenic invaders. Like the rest of the immune system, the innate immune system has to be carefully controlled, and ...

A new Northwestern Medicine study has revealed how a common inherited mutation disrupts red blood cell development and sparks inflammation that can lead to leukemia, according to findings published in ...

New research has revealed how a common inherited mutation in the DDX41 gene – one of the most common genetic risk factors for bone marrow cancers – can disrupt red blood cell development and activate ...

Rasika Venkataraman, a third-year doctoral student working in the lab of Stanley Lee, PhD, at Fred Hutch Cancer Center, has been honored with the 2024 ASH Graduate Hematology Award for her research on ...

This is a case report of individualized therapy for DDX41-mutated AML. The investigators obtained consent from the patient presented in this report to publish information containing medical history, ...

Biallelic DDX41 mutations cause cell death of blood progenitor cells, leading to bone marrow failure and atrophy of the spleen in genetic mouse models. Disclaimer: AAAS and EurekAlert! are not ...

The case study, which showed prolonged disease control achieved with gilteritinib in a previously-treated patient with AML with an inv(2)(p23q13) translocation, indicates that gilteritinib can also be ...