Nucleotide synthesis—the production of the basic components of DNA and RNA—is essential for cell growth and division. In most ...

New findings show that the genome’s 3D structure is constantly changing, with NIPBL guiding loop formation that regulates active genes. Faulty folding dynamics may underlie cancers and developmental ...

The DNA of human cells consists of a sequence of about 3.1 billion building blocks. Cells go to great lengths to maintain the integrity of this vast store of information. They constantly untangle ...

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells. How genes are turned on ...

Researchers have used a new human reference genome, which includes many duplicated and repeat sequences left out of the original human genome draft, to identify genes that make the human brain ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...